Adverse childhood experiences, their social determinants, and risk of young-onset breast cancer subtypes in non-Hispanic Black and White women

Abstract

Background: There are significant disparities in the incidence of young-onset breast cancer (YOBC) tumor subtypes and the etiology of YOBC subtypes is not well understood. Adverse childhood experiences (ACEs) have been hypothesized to increase BC risk, but to-date no studies have evaluated associations between ACEs and YOBC subtypes nor whether associations are mediated by BC risk factors, like adult body size. Here, I examine social determinants of ACEs (i.e., childhood neighborhood poverty rate (cNPR), childhood household SEP (chSEP) index, race/racism); associations between ACEs and body size and whether social determinants modify these associations; and associations between ACEs and YOBC subtypes, and whether social determinants modify and/or adult body size mediates associations. Methods: Data are from the Young Women’s Health History Study, a population-based case (n=1812)-control (n=1381) study of invasive YOBC (diagnosed aged