Antibody Binding Study of Mucin Peptide Epitopes

Abstract

Normal mucin is a class of large heavily glycosylated protein that is expressed on apical epithelial cell surfaces. Tumor mucin contains reduced carbohydrate chains that induces an immunologic response. This study may have implications in the area of peptide epitope-protein carrier complex for invoking the immune system. This study investigated whether or not a shortened mucin peptide epitope and substituted mucin peptides will still be recognized by a specific antibody.