Synthesis and Antibody Binding Study of a Cyclic Dimer MUC1 Mucin Peptide

Abstract

MUC-1 mucins are attracting interests as study targets in the development of vaccines against cancer. MUC-1 mucins are large transmembrane glycoproteins that consist of a 20 amino acid tandem repeat unit (GVTSAPDTRPAPGSTAPPAH) on its extracellular domain (1,2). In an attempt to engineer an optimal peptide antigen, the purpose of this study was to synthesize and examine the structure and monoclonal antibody binding ability of a cyclic dimer form of the 7-residue mucin peptide with sequence GVTSAPD.