Parametric Studies of Melt Electrospinning Poly ?(caprolactone) Fibers for Tissue Engineering Applications

Abstract

The process of electrospinning has received remarkable amount of attention as this technique can be used to fabricate suitable scaffolds for cells. In order to control morphology of scaffold, parametric studies are necessary in customized melt electrospinning. In this study, we demonstrate that fiber diameter could be controlled by customized nozzle and parameters which are temperature, voltage, and distance influence to fiber diameter. Moreover, we culture and seed murine CE3 stem cells derived from D3 embryonic stem cell line on fabricated scaffolds. Overall, scaffold controlled by parameter studies holds a promising strategy for superb cell attachment and proliferation.