Utilizing oscillating magnetic fields to manipulate embryonic tissues

Abstract

Embryonic mouse tissues were incubated with gold-coated iron conjugated to a p75 antibody and then exposed to an oscillating magnetic field (OM). The p75 antibodies tag neural crest-derived cells, and via this interaction these cells can be differentially killed when treated with the OMF. These results suggest that this approach can be used to manipulate embryonic cells, but future study is required to confirm these results. Problems did occur during the experiment, and perhaps they can be explained by the conjugation process not working or possibly because the antibody/metal conjugate could not reach its destination within the tissues. Various approaches can be taken in the future to understand where problems arise and to find solutions to them.