Yohimbine-Induced Circadian Clock Resetting in Mice

Abstract

Mice are nocturnal animals that exhibit predictable activity patterns controlled by their internal (circadian) clock. This study demonstrated that a mouse's circadian clock can be reset to an earlier time through the administration of yohimbine, a selective adrenergic agonist. This study also looks at whether the yohimbine's clock resetting effect is dependent on the time of day at which it is administered.