Polyamide-chlorambucil conjugates

Abstract

Polyamides are chemically engineered molecules made up of sequences of pyrolle and imidazole rings. In particular sequences, these molecules have been shown to have a very high affinity and specificity for nucleic acids, and can therefore be arranged to bind a specific sequence of DNA. By combining such a compound with a known anti-cancer agent, Chlorambucil, and using microarray technology to query the specificity and affinity with which this conjugate binds DNA, and in particular which sequences are bound