Tanscriptome comparison of ionizing radiation resistant strain of Escherichia coli, CB2000, and naturally occurring strain of Escherichia coli, Founder

Abstract

CB2000 is a strain of Escherichia coli (E. coli) that is extremely resistant to ionizing radiation. It was derived from a colony, referred to as the founder strain, isolated from naturally occurring Escherichia coli K12 MG1655. Using microarray technology developed by Affymetrix, a transcriptome comparison was done on CB2000 and Founder to determine the gene(s) that are differentially expressed in CB2000. A large number of genes which are involved in metabolism, transport and stress response were identified to display changes in expression levels in CB2000 when compared to Founder.