Characterization of Nonphotic Resetting of the Mouse Circadian Clock.

Abstract

We have constructed a phase response curve (PRC), for light-to-dark transitions in male mice showing the phase shifts are specific to the Phase of the daily cycle at which they are administered. As is true for nonphotic PRCs in other species, the mouse PRC shows large advance shifts when animals are stimulated during the normal rest phase and little or no shifting when animals are stimulated during the activity phase. We also asked whether circadian clock resetting was the same in female mice as in males.