Genome Rearrangements with Insertions and Deletions

Abstract

Many mathematical models have been developed to help solve the genome rearrangement problem, whose goal is to find the shortest sequence of mutations for one genome into another. However, few of these consider small segments of DNA in which insertions and deletions are the primary mutations that occur. When developing this model, this study chose to consider Neurofibromatosis (NF), which causes uncontrollable neuron growth leading to tumors, blindness, and learning disabilities. NF is one of several autosomal dominant disorders caused primarily by insertion and deletion mutations during DNA replication.