Investigating Catalytically Important Residues in Escherichia coli Prolyl-tRNA Synthetase Through Site-Directed Mutagenesis
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Authors
Hati, Sanchita
Losbanos, Louis
Weinzetl, Murphi
Adams, Lauren
Hu, Huakun
Bhattacharyay, Sudeep
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Abstract
In the present study, we have employed
site-directed mutagenesis to probe the role of four residues in E. coli ProRS (Ec
ProRS) on the overall catalytic function. Specifically, we examined the impact of
changes in amino acid properties on the interactions between the enzyme (Ec
ProRS) and the substrates, proline and ATP.
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National Institute of Health; University of Wisconsin--Eau Claire Office of Research and Sponsored Programs.